In questa interessante metanalisi sono esaminati vari lavori che prevedono l’utilizzo di PRP nel trattamento di ulcere venose sia come dressing che in forma iniettiva perilesionale. Si evidenzia l’efficacia del PRP nel trattamento di questo tipo di lesioni, ma è interessante anche un endopoint secondario che evidenzia un più basso tasso di recidiva con il PRP, verosimilmente indicando una migliore qualità delle cicatrici prodotte.
This interesting meta-analysis examines various works involving the use of PRP in the treatment of venous ulcers both as a dressing and in perilesional injection form. The effectiveness of PRP in the treatment of this type of lesions is highlighted, but a secondary endopoint is also interesting which highlights a lower rate of recurrence with PRP, probably indicating a better quality of the scars produced.
(dott. Rosario Miranda, MD)
Forest plot depicting meta‐analysis of safety outcomes. CI, confidence interval; OR, odds ratio; PRP, platelet‐rich plasma. *indicates different studies from the same literature.
Hu Z, Wang S, Yang H, Xv H, Shan B, Lin L, Han X. Efficacy and safety of platelet-rich plasma in the treatment of venous ulcers: A systematic review and meta-analysis of randomized controlled trials. Int Wound J. 2024 Feb;21(2):e14736.
Abstract
Considering the substantial impact of venous ulcers on quality of life and healthcare systems, this study evaluated the efficacy and safety of platelet-rich plasma (PRP) in comparison to conventional therapy. A systematic review of four databases identified 16 randomized clinical trials, including 20 study groups. PRP significantly enhanced complete ulcer healing, exhibiting an odds ratio (OR) of 5.06 (95% confidence interval [CI]: 2.35-10.89), and increased the percentage of healed ulcer area by a mean difference of 47% (95% CI: 32%-62%). Additionally, PRP shortened the time required for complete healing by an average of 3.25 months (95% CI: -4.06 to -2.43). Although pain reduction was similar in both groups, PRP considerably decreased ulcer recurrence rates (OR = 0.16, 95% CI: 0.05-0.50) without increasing the risks of infection or irritative dermatitis. These results suggest PRP as a viable, safe alternative for venous ulcer treatment, providing significant improvements in healing outcomes.
Keywords: efficacy; meta-analysis; platelet-rich plasma; safety; venous ulcer.
This interesting meta-analysis examines various works involving the use of PRP in the treatment of venous ulcers both as a dressing and in perilesional injection form. The effectiveness of PRP in the treatment of this type of lesions is highlighted, but a secondary endopoint is also interesting which highlights a lower rate of recurrence with PRP, probably indicating a better quality of the scars produced.
(dott. Rosario Miranda, MD)
Forest plot depicting meta‐analysis of safety outcomes. CI, confidence interval; OR, odds ratio; PRP, platelet‐rich plasma. *indicates different studies from the same literature.
Hu Z, Wang S, Yang H, Xv H, Shan B, Lin L, Han X. Efficacy and safety of platelet-rich plasma in the treatment of venous ulcers: A systematic review and meta-analysis of randomized controlled trials. Int Wound J. 2024 Feb;21(2):e14736.
Abstract
Considering the substantial impact of venous ulcers on quality of life and healthcare systems, this study evaluated the efficacy and safety of platelet-rich plasma (PRP) in comparison to conventional therapy. A systematic review of four databases identified 16 randomized clinical trials, including 20 study groups. PRP significantly enhanced complete ulcer healing, exhibiting an odds ratio (OR) of 5.06 (95% confidence interval [CI]: 2.35-10.89), and increased the percentage of healed ulcer area by a mean difference of 47% (95% CI: 32%-62%). Additionally, PRP shortened the time required for complete healing by an average of 3.25 months (95% CI: -4.06 to -2.43). Although pain reduction was similar in both groups, PRP considerably decreased ulcer recurrence rates (OR = 0.16, 95% CI: 0.05-0.50) without increasing the risks of infection or irritative dermatitis. These results suggest PRP as a viable, safe alternative for venous ulcer treatment, providing significant improvements in healing outcomes.
Keywords: efficacy; meta-analysis; platelet-rich plasma; safety; venous ulcer.
