Questa rewiew narrativa analizza le interazioni tra biomateriali e concentrati piastrinici con l’obiettivo di ottimizzare i processi riparativi. In particolare sono esaminati biomateriali utilizzati come sostituti cutanei, per la rigenerazione di nervi, della cartilagine, dell’ osso. In tutte queste applicazioni sembra che l’associazione con concentrati piastrinici ne migliori l’efficacia probabilmente grazie ad una maggiore disponibilità di fattori di crescita ed una più robusta angiogenesi.
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This narrative review analyzes the interactions between biomaterials and platelet concentrates with the aim of optimizing repair processes. In particular, biomaterials used as skin substitutes for the regeneration of nerves, cartilage and bone are examined. In all these applications it seems that the association with platelet concentrates improves their efficacy probably thanks to a greater availability of growth factors and a stronger angiogenesis.
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(dott. Miranda Rosario)
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Grzelak A, Hnydka A, Higuchi J, Michalak A, Tarczynska M, Gaweda K, Klimek K. Recent Achievements in the Development of Biomaterials Improved with Platelet Concentrates for Soft and Hard Tissue Engineering Applications. Int J Mol Sci. 2024 Jan 26;25(3):1525.
pubmed.ncbi.nlm.nih.gov/38338805/
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Abstract
Platelet concentrates such as platelet-rich plasma, platelet-rich fibrin or concentrated growth factors are cost-effective autologous preparations containing various growth factors, including platelet-derived growth factor, transforming growth factor β, insulin-like growth factor 1 and vascular endothelial growth factor. For this reason, they are often used in regenerative medicine to treat wounds, nerve damage as well as cartilage and bone defects. Unfortunately, after administration, these preparations release growth factors very quickly, which lose their activity rapidly. As a consequence, this results in the need to repeat the therapy, which is associated with additional pain and discomfort for the patient. Recent research shows that combining platelet concentrates with biomaterials overcomes this problem because growth factors are released in a more sustainable manner. Moreover, this concept fits into the latest trends in tissue engineering, which include biomaterials, bioactive factors and cells. Therefore, this review presents the latest literature reports on the properties of biomaterials enriched with platelet concentrates for applications in skin, nerve, cartilage and bone tissue engineering.
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Keywords
bone; cartilage; concentrated growth factors; nerve; platelet lysate; platelet-rich fibrin; platelet-rich plasma; regenerative medicine; scaffold; skin.
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This narrative review analyzes the interactions between biomaterials and platelet concentrates with the aim of optimizing repair processes. In particular, biomaterials used as skin substitutes for the regeneration of nerves, cartilage and bone are examined. In all these applications it seems that the association with platelet concentrates improves their efficacy probably thanks to a greater availability of growth factors and a stronger angiogenesis.
.
(dott. Miranda Rosario)
.
.
Grzelak A, Hnydka A, Higuchi J, Michalak A, Tarczynska M, Gaweda K, Klimek K. Recent Achievements in the Development of Biomaterials Improved with Platelet Concentrates for Soft and Hard Tissue Engineering Applications. Int J Mol Sci. 2024 Jan 26;25(3):1525.
pubmed.ncbi.nlm.nih.gov/38338805/
.
Abstract
Platelet concentrates such as platelet-rich plasma, platelet-rich fibrin or concentrated growth factors are cost-effective autologous preparations containing various growth factors, including platelet-derived growth factor, transforming growth factor β, insulin-like growth factor 1 and vascular endothelial growth factor. For this reason, they are often used in regenerative medicine to treat wounds, nerve damage as well as cartilage and bone defects. Unfortunately, after administration, these preparations release growth factors very quickly, which lose their activity rapidly. As a consequence, this results in the need to repeat the therapy, which is associated with additional pain and discomfort for the patient. Recent research shows that combining platelet concentrates with biomaterials overcomes this problem because growth factors are released in a more sustainable manner. Moreover, this concept fits into the latest trends in tissue engineering, which include biomaterials, bioactive factors and cells. Therefore, this review presents the latest literature reports on the properties of biomaterials enriched with platelet concentrates for applications in skin, nerve, cartilage and bone tissue engineering.
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Keywords
bone; cartilage; concentrated growth factors; nerve; platelet lysate; platelet-rich fibrin; platelet-rich plasma; regenerative medicine; scaffold; skin.
